OmniVira

Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2.

Jianzhong Shi1 Zhiyuan Wen1 Gongxun Zhong1 Huanliang Yang1 Chong Wang1 Baoying Huang2 Renqiang Liu1 Xijun He3 Lei Shuai1 Ziruo Sun1 Yubo Zhao1 Peipei Liu2 Libin Liang1 Pengfei Cui1 Jinliang Wang1 Xianfeng Zhang3 Yuntao Guan3 Wenjie Tan2 Guizhen Wu4 Hualan Chen5 Zhigao Bu5,3
Affiliations 5 institutions
  1. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, People's Republic of China.
  2. National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, People's Republic of China.
  3. National High Containment Laboratory for Animal Diseases Control and Prevention, Harbin 150069, People's Republic of China.
  4. National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, People's Republic of China. [email protected] [email protected] [email protected].
  5. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, People's Republic of China. [email protected] [email protected] [email protected].
PMID32269068 DOI10.1126/science.abb7015 Year2020 Journal Science (New York, N.Y.) Science Languageeng Statusppublish

Abstract

Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) causes the infectious disease COVID-19 (coronavirus disease 2019), which was first reported in Wuhan, China, in December 2019. Despite extensive efforts to control the disease, COVID-19 has now spread to more than 100 countries and caused a global pandemic. SARS-CoV-2 is thought to have originated in bats; however, the intermediate animal sources of the virus are unknown. In this study, we investigated the susceptibility of ferrets and animals in close contact with humans to SARS-CoV-2. We found that SARS-CoV-2 replicates poorly in dogs, pigs, chickens, and ducks, but ferrets and cats are permissive to infection. Additionally, cats are susceptible to airborne transmission. Our study provides insights into the animal models for SARS-CoV-2 and animal management for COVID-19 control.

Supporting text Virus Host Location
Animals, Domestic 35 Coronavirus Infections 171 Disease Models, Animal 77 Disease Susceptibility 21 Ferrets 79 Pandemics 108 Pneumonia, Viral 42 Animals 1948 Antibodies, Viral 212 Betacoronavirus 78 Cats 120 Chickens 146 COVID-19 425 Dogs 176 Ducks 81 Feces 113 Female 289 Male 224 Respiratory System 21 RNA, Viral 193 SARS-CoV-2 453 Species Specificity 84 Sus scrofa 30 Virus Attachment 55

Evidence records

1 total
Experimental Infection
1 records · 1 evidence types
Evidence type Host Range Experiment
1 records
OVE11559 Host Range Experiment
Key finding

Ferrets and cats were permissive to infection with SARS-CoV-2, whereas dogs, pigs, chickens, and ducks showed poor replication in controlled infection experiments.

Virus
Severe acute respiratory syndrome coronavirus 2
Host
domestic ferret Mustela putorius furo Experimental system domestic cat Felis catus Experimental system dog Canis lupus familiaris Experimental system pig Sus scrofa Experimental system chicken Gallus gallus Experimental system ducks Anas Experimental system
Location
Not specified
Supporting text

We found that SARS-CoV-2 replicates poorly in dogs, pigs, chickens, and ducks, but ferrets and cats are permissive to infection.

Method
experimental infection | viral replication assay
Experimental system
animal infection model