We report here the complete genomic sequence of an avian-like H4N8 swine influenza virus containing an H5N1 avian influenza virus segment from swine in southern China. Phylogenetic analyses of the sequences of all eight viral RNA segments demonstrated that these are wholly avian influenza viruses of the Asia lineage. To our knowledge, this is the first report of interspecies transmission of an avian H4N8 influenza virus to domestic pigs under natural conditions.
Genome, ViralAnimalsBase SequenceChinaInfluenza A virusMolecular Sequence DataOrthomyxoviridae InfectionsPhylogenySwineSwine Diseases
Structured evidence records
Evidence records
3 total
Cross Species Transmission1 records
Cross Species TransmissionExtraction confidence 0.95
Key finding
An avian H4N8 influenza virus was transmitted from birds to domestic pigs in southern China under natural conditions.
To our knowledge, this is the first report of interspecies transmission of an avian H4N8 influenza virus to domestic pigs under natural conditions.
Method
genome sequencing; phylogenetic analysis
Study design
phylogenetic analysis
Transmission direction
animal-to-animal
Geographic raw
southern China
Country inferred
China
Genomic Evolution1 records
Genomic EvolutionExtraction confidence 0.90
Key finding
Genomic sequencing and phylogenetic analysis revealed that the H4N8 swine influenza virus possesses entirely avian-origin gene segments, suggesting cross-species transmission from avian hosts to pigs in China.
We report here the complete genomic sequence of an avian-like H4N8 swine influenza virus containing an H5N1 avian influenza virus segment from swine in southern China. Phylogenetic analyses of the sequences of all eight viral RNA segments demonstrated that these are wholly avian influenza viruses of the Asia lineage.
Genes or proteins
eight viral RNA segments
Analysis methods
complete genome sequencing; phylogenetic analysis
Recombination Or Reassortment1 records
Recombination Or ReassortmentExtraction confidence 0.85
Key finding
An avian-like H4N8 swine influenza virus isolated from pigs in southern China carries an H5N1 avian influenza virus segment, indicating reassortment between avian influenza strains.
We report here the complete genomic sequence of an avian-like H4N8 swine influenza virus containing an H5N1 avian influenza virus segment from swine in southern China.
Event type
reassortment
Citation context
References
3 references
Reference network
Force-directed citation graph. OmniVira-indexed references are prioritized and recursively expanded up to three steps.
2001. Cocirculation of avian H9N2 and contemporary “human” H3N2 influenza A viruses in pigs in southeastern China: potential for genetic reassortment? J
Peiris
2001
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1990/1991. Pigs as “mixing vessels” for the creation of new pandemic influenza A viruses
