OmniVira

Zoonotic spill-over of SARS-CoV-2: mink-adapted virus in humans.

Lukasz Rabalski1 Maciej Kosinski1 Natalia Mazur-Panasiuk2 Boguslaw Szewczyk1 Krystyna Bienkowska-Szewczyk1 Ravi Kant3 Tarja Sironen3 Krzysztof Pyrc4 Maciej Grzybek5
Affiliations 5 institutions
  1. Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, Gdańsk, Poland.
  2. Małopolska Centre of Biotechnology, Jagiellonian University, Kraków, Poland.
  3. Department of Virology, University of Helsinki, Helsinki, Finland.
  4. Małopolska Centre of Biotechnology, Jagiellonian University, Kraków, Poland. Electronic address: [email protected].
  5. Institute of Maritime and Tropical Medicine, Medical University of Gdańsk, Gdynia, Poland. Electronic address: [email protected].
PMID34920116 DOI10.1016/j.cmi.2021.12.001 Year2022 Journal Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases Clin Microbiol Infect Languageeng Statusppublish

Abstract

This work aimed to analyse possible zoonotic spill-over of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report the spill-over of mink-adapted SARS-CoV-2 from farmed mink to humans after adaptation that lasted at least 3 months. Next-generation sequencing and a bioinformatic approach were applied to analyse the data. In an isolate obtained from an asymptomatic patient testing positive for SARS-CoV-2, we found four distinguishing mutations in the S gene that gave rise to the mink-adapted variant (G75V, M177T, Y453F, and C1247F) and others. Zoonotic spill-over of SARS-CoV-2 can occur from mink to human.

Supporting text Virus Host Location
Mink 58 SARS-CoV-2 550 Spill-over 5 Transmission 55 Zoonoses 477 COVID-19 425 SARS-CoV-2 453 Animals 1948 Farms 30 Humans 1440 Mink 48 Zoonoses 397

Evidence records

2 total
Transmission Evidence
1 records · 1 evidence types
Evidence type Spillover Event
1 records
OVE5454 Spillover Event
Key finding

Mink-adapted SARS-CoV-2 spilled over naturally from farmed mink to humans after several months of viral adaptation.

Virus
Severe acute respiratory syndrome coronavirus 2
Host
human Homo sapiens Natural host weasel, mink, badger, martens and others Mustelidae Natural host
Location
Not specified
Supporting text

We report the spill-over of mink-adapted SARS-CoV-2 from farmed mink to humans after adaptation that lasted at least 3 months.

Method
next-generation sequencing | bioinformatic analysis
Study design
observational genomic study of natural zoonotic transmission
Transmission direction
animal-to-human
Functional Mechanism
1 records · 1 evidence types
Evidence type Molecular Adaptation
1 records
OVE5455 Molecular Adaptation
Key finding

A mink-adapted SARS-CoV-2 variant isolated from a human carried spike gene mutations G75V, M177T, Y453F, and C1247F associated with adaptation to mink hosts.

Virus
Severe acute respiratory syndrome coronavirus 2
Host
Not specified
Location
Not specified
Supporting text

In an isolate obtained from an asymptomatic patient testing positive for SARS-CoV-2, we found four distinguishing mutations in the S gene that gave rise to the mink-adapted variant (G75V, M177T, Y453F, and C1247F) and others.

Genes or proteins
S gene | spike protein
Mutations
G75V | M177T | Y453F | C1247F
Mechanism types
host-range expansion | receptor binding